11
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T38139 | Orexin receptor antagonist 2 | ||
Orexin Receptor Antagonist 2 (compound 30), characterized by its potent antagonistic activity with pKis of 7.69 and 9.78, holds promise for insomnia research[1]. | |||
T26559 | ACT-462206 | OX Receptor | |
ACT-462206 is an orally available Orexin 1/Orexin 2 receptor antagonist that crosses the blood-brain barrier.ACT-462206 is highly potent and can be used in studies of sleep and anxiety. | |||
T2613 | Almorexant | ACT 078573 | OX Receptor |
Almorexant (ACT 078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. | |||
T3722 | MK-1064 | Urokinase inhibitor 1,MK 1064 | OX Receptor |
MK-1064 (Urokinase inhibitor 1) is a selective orexin 2 receptor antagonist (2-SORA). | |||
T1913 | MK-3697 | OX Receptor | |
MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM). | |||
T12877L | Seltorexant | JNJ-42847922 | OX Receptor |
Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective orexin-2 receptor antagonist (pKi: 8.0 and 8.1 for human a... | |||
T62050 | Orexin receptor antagonist 4 | ||
Orexin receptor antagonist 4 is potent and selective orexin 2 receptor (OX2R) antagonist. Orexin receptor antagonist 4 shows IC50 of 4.27 nM and 295 nM for OX2R and OX1R, respectively. | |||
T28060 | MK-8133 | ||
MK-8133 is an antagonist of orexin-2 selective receptor with favorable development properties. | |||
T69715 | ORN-0829 hydrate | ||
ORN-0829 hydrate is a potent dual orexin 1/2 receptor antagonist for the treatment of insomnia. | |||
T4965L | TCS-OX2-29 HCl | TCSOX 229,TCS-OX229,TCS OX229,TCS OX2 29,TCSOX-229,TCSOX229 | |
TCS-OX2-29 is a selective orexin-2 receptor antagonist (IC50 = 40 nM), which plays an important role in pain modulation. | |||
T6155 | Almorexant hydrochloride | ACT-078573 hydrochloride,Almorexant HCl | OX Receptor |
Almorexant hydrochloride (ACT-078573 hydrochloride) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. |